Recently, I have noticed that the "Recent Wiki Edits" box (equivalently, this page) in the sidebar seems to be almost exclusively filled with the edits from spam bots and either Gwern or Vladimir Nesov cleaning up after them (thanks!). This seems like it should be fixed, if only to save those two the time they spend on maintenance.
The wiki registration form does have a reCAPTCHA in an attempt to block spam-bots, but this is apparently not effective enough (maybe because reCAPTCHA has been cracked, or the spammers are using humans in some way).
I have some possible solutions, but I shall wait a bit before suggesting them.
(I vaguely remember there being a discussion like this previously, but I can't find it again, if it exists.)
I've found that the cognitive reflection test is a very nearly 100% effective "captcha" for wikis and forums. None of the image-based captchas I've used have been anywhere near as effective. Apparently a lot of spam posting is done using humans, but they aren't smart enough to pass the CRT. (Obviously, this will stop working if enough sites start using it and the answers become well known.)